A collaboration between WPI and ENSIC was undertaken to investigate the properties of emulsions as a drug delivery system. Biocompatible amphiphilic polymers are used as emulsifiers for controlled drug delivery. They act as a barrier between phases in oil-in-water emulsions to increase stability. Oil soluble drugs can be encapsulated within the oil nanoparticles and released into a biological system. The goal of this project was to study modified dextran (DexC6), an amphiphilic polymer. The most stable emulsions were formed with a DexC6 aqueous concentration of 40g/L in a system of 40% octyldodecanol oil volume. Drug release kinetic experiments showed that encapsulated lidocaine is released at a slower rate than free lidocaine. Further research in emulsion drug delivery is recommended.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Regan, Matthew J.
• King, Ashley J.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042506-120742

Advisor

• Camesano, Terri Anne
• McGimpsey, W. Grant

Year

• 2006

Center

• Nancy, France Project Center - MQP

Sponsor

• ENSIC

Date created

• 2006-04-25

Location

• Nancy

Resource type

• Major Qualifying Project

Major

• Chemical Engineering

Rights statement

• In Copyright