Modified Dextran Polymers for Drug Delivery
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open in viewerA collaboration between WPI and ENSIC was undertaken to investigate the properties of emulsions as a drug delivery system. Biocompatible amphiphilic polymers are used as emulsifiers for controlled drug delivery. They act as a barrier between phases in oil-in-water emulsions to increase stability. Oil soluble drugs can be encapsulated within the oil nanoparticles and released into a biological system. The goal of this project was to study modified dextran (DexC6), an amphiphilic polymer. The most stable emulsions were formed with a DexC6 aqueous concentration of 40g/L in a system of 40% octyldodecanol oil volume. Drug release kinetic experiments showed that encapsulated lidocaine is released at a slower rate than free lidocaine. Further research in emulsion drug delivery is recommended.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042506-120742
- Advisor
- Year
- 2006
- Center
- Sponsor
- Date created
- 2006-04-25
- Location
- Nancy
- Resource type
- Major
- Rights statement
Relations
- In Collection:
Items
Items
Thumbnail | Title | Visibility | Embargo Release Date | Actions |
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Drug_Delivery_Final_MQP_2006.pdf | Public | Download | ||
Final_Drug_Delivery_Poster_2006.ppt | Public | Download |
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