An infertile C. elegans mutant fer-1 was identified as a suitable substitute for wild type in evaluating the pathogenesis of C. albicans using a survival assay. The response of fer-1 mutant worms infected with avirulent C. albicans mutants or treated with fluconazole is statistically indistinguishable from the wildtype counterpart. The lifespan of uninfected fer-1 worms is marginally yet reproducibly shorter than wildtype, but the lack of progeny in sterile mutants makes them an ideal choice for otherwise labor-intensive lifespan analyses.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Post, Stephanie Elaine
• Sears, Tracy Lynn

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042212-192727

Advisor

• Rao, Reeta Prusty
• Heilman, Destin

Year

• 2012

Date created

• 2012-04-22

Resource type

• Major Qualifying Project

Major

• Interdisciplinary

Rights statement

• In Copyright

Last modified

• 2021-02-02