Designing a Fibrin Scaffold for Lung Resident Mesenchymal Stem Cell Therapy in Emphysema Patients
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open in viewerBased on promising results seen in regenerative therapies for wound healing, this study explores the use of delivering stem cells through a fibrin hydrogel for the treatment of emphysema. To determine an optimal formulation of the biopolymer fibrin, gene expression of lung resident mesenchymal stem cells (LR-MSCs) was studied in three different scaffold formulations. In addition, mechanical modeling was completed to correlate any uncharacteristic behavior with a change in mechanical properties. The results from the study indicated that 3 mg/mL fibrinogen with 500U thrombin may be optimal; however, additional testing needs to be completed to validate mechanical modeling and demonstrate the potency potential of LR-MSCs on secondary cell lines.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Contributors
- Publisher
- Identifier
- E-project-043014-171250
- Advisor
- Year
- 2014
- Sponsor
- Date created
- 2014-04-30
- Resource type
- Major
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