Copper-catalyzed methods for benzylic C-H bond amination
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open in viewerBenzylic amines are key components of biologically significant compounds and can be found in several top-selling prescription drugs. As such, developing facile syntheses for complex, biologically-important compounds is an important issue facing the pharmaceutical industry. While catalysis can typically design “greener” reactions, current catalytic syntheses of benzylic amines utilize hazardous or waste-intensive reagents and often fail to synthesize useful products in one step. Our studies sought to develop Cu-catalyzed systems for benzylic aminations through the use of novel amination reagents. Cu precursors, ligands, and additives have been surveyed to establish efficient reactions that generate benzylic C-N bonds directly from benzylic C-H bonds in a one pot, single step synthesis.
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- Creator
- Publisher
- Identifier
- E-project-043014-123423
- Advisor
- Year
- 2014
- Date created
- 2014-04-30
- Resource type
- Major
- Rights statement
- Last modified
- 2020-12-29
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