Student Work

Targets of Filastatin, A Chemical Inhibitor of Adhesion and Morphogenesis by Pathogenic Fungi

Public

Downloadable Content

open in viewer

Candida albicans is one of the most common fungal pathogens associated with opportunistic and nosocomial infections. Infection is often initiated through formation of a biofilm, which is also drug resistant. A recently discovered small molecule called filastatin shows some promise as an inhibitor of biofilm formation and adhesion to polystyrene. A high-throughput screening assay was performed using a deletion mutant library in order to determine the functional pathway of filastatin. Results indicate that our drug may play a role in disrupting the iron metabolism pathway, particularly through genes regulated through Hap43 and Rim101.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Contributors
Publisher
Identifier
  • E-project-050114-100341
Advisor
Year
  • 2014
Date created
  • 2014-05-01
Resource type
Major
Rights statement

Relations

In Collection:

Items

Items

Permanent link to this page: https://digital.wpi.edu/show/3r074w247