Cellular senescence is a tumor suppressive mechanism that limits growth of human cells by causing cell cycle arrest in G1 phase. Senescence has been of wide interest in recent years because of its link to human cancers. The onset of senescence is caused by repression of transcription through the remodeling of chromatin. This project is focused on developing strategies to identify the role of three chromatin regulating proteins implicated in senescence--ASF1a, ARID4B, and prohibitin.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Ruhl, Victoria E

Contributors

• Kaufman, Paul D.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-031207-123444

Advisor

• Rulfs, Jill

Year

• 2007

Sponsor

• University of Massachusetts Medical School

Date created

• 2007-03-12

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright

Last modified

• 2023-09-27