Cytoplasmic adaptor MIG-10 plays a role in neuronal migration and process outgrowth in C. elegans. Data from a yeast-two hybrid assay indicate that MIG-10 interacts with ABI-1, a protein involved in regulation of actin polymerization and required for neuronal migration and outgrowth. To further characterize the interaction between MIG-10 and ABI-1, deletion mutants were created and co-immunoprecipitation assays and western blots were performed. Preliminary results indicate that the C-terminal SH3 region of ABI-1 is required for its interaction with MIG-10.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Reis-Silvia, Andrea

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042512-222853

Advisor

• Ryder, Elizabeth F.
• Wobbe, Kristin K.

Year

• 2012

Date created

• 2012-04-25

Resource type

• Major Qualifying Project

Major

• Interdisciplinary

Rights statement

• In Copyright