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Do ARX-3 and CSN-5 Protein Subunits Interact with MIG-10 to Promote Axon Outgrowth and Neuronal Migration in C. elegans?

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During nervous system development, the cytoplasmic signaling protein MIG-10 activates cellular processes in response to guidance cues which ultimately lead to axonal growth and migration. Interactions between MIG-10 and two candidate downstream proteins, CSN-5 and ARX-3, were studied in vivo, using mutant transgenic C. elegans strains, and in vitro, using a co-immunoprecipitation system. Preliminary results indicate interaction in vitro between MIG-10 and both proteins. In vivo experiments are ongoing.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-053112-103844
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  • 2012
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  • 2012-05-31
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Permanent link to this page: https://digital.wpi.edu/show/sn00b0587