Student Work

Enantiomeric Separation of Racemic Drugs Using Chiral Self-Assembled Monolayers

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Enantiomeric separation of racemic drugs is a never ending battle for pharmaceutical chemists. Conventional approaches to separating enantiomers (mirror-image stereoisomers) typically rely on chromatography utilizing chiral stationary phases or reactions of racemic drugs with chiral resolving reagents to form diastereomeric salts that crystallize separately. Separation of enantiomers by those techniques is often difficult and can add significantly to the cost of developing and marketing racemic drugs. The objective of this project was to develop a new surface-based approach to separating enantiomers of racemic drugs via selective crystallization on chiral surfaces consisting of gold substrates functionalized with self-assembled monolayers (SAMs) of a chiral organic compound.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042810-152301
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Year
  • 2010
Date created
  • 2010-04-28
Location
  • Zurich
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