Fungal infections caused by Candida albicans are more common today than ever before. Higher morbidity and mortality rates associated with drug resistance have increased the need for the development of more effective compounds that enhance marketed antifungal activity. In this study, the anticandidal activity of the terpenoid component of the plant essential oil, Geraniol, was investigated. This was achieved using minimum inhibitory concentration assays (MIC) on resistant C. albicans strains. The synergistic activity of Geraniol combined with the known azole Fluconazole was also evaluated using Checkerboard Assays for increased efficacy against C. albicans in vitro. The data indicate a synergistic activity of the Geraniol-Fluconazole mixture against drug-resistant C. albicans.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Kamara, Jennifer Victoria
• Ismail, Hashim Hassan

Contributors

• Gary, Ostroff

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042512-200509

Advisor

• Adams, David S.
• Camesano, Terri Anne

Year

• 2012

Sponsor

• UMass Medical School

Date created

• 2012-04-25

Resource type

• Major Qualifying Project

Major

• Chemical Engineering
• Biochemistry

Rights statement

• In Copyright