Student Work
Gadd45-α and Metastatic Hepatocellular Carcinoma Cell Migration
PublicDownloadable Content
open in viewerGadd45-alpha is a tumor suppressor protein identified by microarray analysis with a reduced expression in hepatocellular carcinoma (HCC) cell lines with high migration ability. The role of Gadd45-alpha in HCC migration was tested by stable shRNA knockdowns in a non-metastasizing murine cell line (BL185). The migration levels of the Gadd45-alpha knockdowns were significantly increased relative to the parental non-metastasizing line, indicating that decreased Gadd45-alpha expression is sufficient to promote increased cell migration.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042310-144004
- Advisor
- Year
- 2010
- Sponsor
- Date created
- 2010-04-23
- Resource type
- Major
- Rights statement
Relations
- In Collection:
Items
Items
Thumbnail | Title | Visibility | Embargo Release Date | Actions |
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Sally_Trabucco_MQP_Final.pdf | Public | Download |
Permanent link to this page: https://digital.wpi.edu/show/5999n502t