Student Work

Gadd45-α and Metastatic Hepatocellular Carcinoma Cell Migration

Public

Downloadable Content

open in viewer

Gadd45-alpha is a tumor suppressor protein identified by microarray analysis with a reduced expression in hepatocellular carcinoma (HCC) cell lines with high migration ability. The role of Gadd45-alpha in HCC migration was tested by stable shRNA knockdowns in a non-metastasizing murine cell line (BL185). The migration levels of the Gadd45-alpha knockdowns were significantly increased relative to the parental non-metastasizing line, indicating that decreased Gadd45-alpha expression is sufficient to promote increased cell migration.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • E-project-042310-144004
Advisor
Year
  • 2010
Sponsor
Date created
  • 2010-04-23
Resource type
Major
Rights statement

Relations

In Collection:

Items

Items

Permanent link to this page: https://digital.wpi.edu/show/5999n502t