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Effect of Gasdermin D on Pyroptosis in Mouse Macrophages

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Gasdermin D (GSDMD) is a protein encoded by the GSDMD gene and is found in the epithelial tissue and immune cells of humans. GSDMD is known to be cleaved into two segments, the pore forming domain on the N-terminal and the repressor domain on the C-terminal, by inflammatory caspases 1, 4, 5, and 11. Various bacterial strains were used to infect mouse macrophages with and without the GSDMD gene. The quantified difference in cell death between the two groups emphasizes the role of the GSDMD protein in the pyroptosis pathway.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042518-165929
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  • 2018
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  • 2018-04-25
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