Interaction with the CD4 co-receptor can change tropism in HIV-1. It has been shown that CCR5-using isolates cultured in vitro without the presence of neutralizing antibodies can be more efficient at infection, while at the same time becoming more sensitive to neutralization. This project studies CXCR4-using envelopes examining the effect of viral isolation on tropism, receptor use, and antibody sensitivity. The cultured CXCR4-using isolates did not evolve different properties from the uncultured CXCR4-using isolate.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Dowdy, Christopher R

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-010606-170542

Advisor

• Adams, David S.

Year

• 2006

Sponsor

• UMass Medical Center

Date created

• 2006-01-06

Location

• Nancy

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright