Student Work

Genome Wide Mapping of Murine Genes Controlling Differential Expression of CD5l and CCR2

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Listeria monocytogenes is gram positive bacterium which can cause overt infection in humans through consumption of contaminated food and beverages. Two host genes CD5l and CCR2 play a major role in the innate immune response to such infection. Both CCR2 and CD5l are differentially expressed in mouse strains that differ in their susceptibility to L. monocytogenes infection. Therefore differential expression of these genes could be contributing to susceptibility to infection. The purpose of this project is to determine what regulates these genes at a molecular level through mouse models. A genome wide mapping was performed using 42 N2 backcross mice. A linkage between CD5l and CCR2 expression levels to markers on each chromosome was tested using genetic mapping software (Map Manager).

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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Identifier
  • E-project-042909-124201
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Year
  • 2009
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Date created
  • 2009-04-29
Location
  • Osaka
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