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Bacillus subtilis as a Probiotic: Implications for Inflammatory Bowel Disease and Intestinal Colonization of Candida albicans

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Microbes play a key role in the pathology of inflammatory bowel disease even though the cause remains unknown. Here we report that Caenorhabditis elegans live longer when first exposed to Bacillus subtilis compared to animals exposed to pathogenic fungus Candida albicans alone, suggesting a probiotic effect of B. subtilis biofilm. This result was bolstered by the finding that mutant B. subtilis that are unable to form biofilms are unable to provide protection against C.albicans infection and animals that are unable to mount an immune response are also susceptible to C. albicans despite probiotic treatment.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042717-114332
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  • 2017
Date created
  • 2017-04-27
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Permanent link to this page: https://digital.wpi.edu/show/2v23vw30t