Mutations in genes involved in nervous system development can result in disorders such as Down’s syndrome and autism. MIG-10 is a cytoplasmic adaptor protein in the model system C. elegans that functions in neuronal migration and axon guidance during development. To study possible interactions between MIG-10 and candidate protein CSN-5, co-immunoprecipitation and western blotting were performed. An interaction between MIG-10 and CSN-5 was confirmed, suggesting that CSN-5 is needed to stabilize MIG-10.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Tymon, Roxanne Elizabeth

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042413-220948

Advisor

• Ryder, Elizabeth F.

Year

• 2013

Date created

• 2013-04-24

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright