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Investigating Porcine Circovirus Type 2 Viral Protein 3 Multimerization Capabilities

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Porcine Circovirus Type 2 (PCV-2) is a single-stranded non-enveloped DNA virus belonging to the Circoviridae family that produces a novel viral protein, Viral Protein 3 (VP3) that is suspected of selectively killing transformed human cancer cells via an unknown mechanism. To understand this mechanism, PCV-2 VP3 is often compared to the Chicken Anemia Virus (CAV Apoptin), which has been shown to harbor killing capacity towards transformed cells in a p-53 independent manner. Here we investigate by Fluorescence Resonance Energy Transfer (FRET) PCV-2 VP3’s ability to multimerize as part of a mechanism-of-apoptosis.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042513-143621
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  • 2013
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  • 2013-04-25
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