Prostate cancer (PC) is a leading cause of death for men because of metastasis of the tumor to the skeleton. Using mouse models, we find that Runx2, a transcription factor implicated in PC progression, is present in stromal and epithelial cells of the early PIN (prostatic intraepithelial neoplasia) lesion in the prostate. Runx2 activates target genes involved in metastasis in the prostate by week 16. These results indicate a potential new therapy, focused on Runx2, for prostate cancer.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• King, Catherine Georgia

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042512-125238

Advisor

• Adams, David S.

Year

• 2012

Date created

• 2012-04-25

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright