The C. elegans protein MIG-10 is a cytoplasmic signaling protein known to facilitate neuronal migrations during development of the worm. LIN-53 is a nucleosome remodeling factor associated with transcriptional repression in C. elegans. Biochemical analyses were performed using co-immunoprecipitation and western blotting techniques to assess the interaction of these two proteins. Preliminary results suggest a potential interaction between LIN-53 and MIG-10. Work is in progress to determine whether lin-53 mutations affect neuronal migrations in C. elegans.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Maloney, Erin Eileen

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-060112-141349

Advisor

• Ryder, Elizabeth F.

Year

• 2012

Date created

• 2012-06-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright