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Development Toward the Synthesis of New Pharmacophores

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The concerted [3+2] ylide-alkene photocyclization proceeds through trans-fused ylide intermediates. This reaction has been demonstrated to produce multicyclic heterocycles with up to six chiral centers in excellent yields from simple starting materials. This reaction can be used to develop novel compounds toward the discovery of new pharmacophores. Developments toward an asymmetric variant of this reaction have been undertaken.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-050310-214735
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  • 2010
Date created
  • 2010-05-03
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Permanent link to this page: https://digital.wpi.edu/show/2801pj129