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Dopamine Transporter Internalizes by Means of a Dynamin-Independent Endocytic Pathway

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The Dopamine Transporter (DAT) is a trans-membrane protein that binds dopamine and transports it into the cell, removing it from the synapse and terminating the signal to the post-synaptic cell. The endocytic pathway by which DAT internalizes is yet unknown. Dynamin is a GTPase that is known to be involved in the budding of vesicles during some endocytic pathways. The present study was performed to determine if DAT internalizes via a dynamin-dependent endocytic pathway. Data shows that DAT internalization is not dynamin-dependent and implicates that dynamin may be involved in recycling DAT to the cell surface.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042612-142343
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  • 2012
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  • 2012-04-26
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