The goal of this project was to design a relatively inexpensive, minimally invasive fixation device for the hind limb of a mouse that uses topical electrical stimulation of skeletal muscle to accurately and repeatedly quantify the force generated by muscle contractions. The device also had to be compatible with surgical procedures visualized using a stereomicroscope. Measurements were acquired following multiple series of electrical stimulation by placement of bipolar electrodes on the tibialis anterior muscle surface. There was no visible evidence of tissue damage at either the knee anchor point or at the point of attachment of ligature to the foot, which was connected to the force transducer. Further, there was no visible damage to the muscle tissue due to electrode placement.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Pinnette, Dylan Aldous
• Choate, Bryan P.
• Gonzalez, Gregory Michael
• Yibrah, Jirom Solomon

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042512-154022

Advisor

• Page, Raymond L.

Year

• 2012

Sponsor

• Raymond Page

Date created

• 2012-04-25

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright