The Influenza A virus is a highly pathogenic virus with the potential to cause major pandemics and annual outbreaks. The goal of this project is to investigate the highly conserved trimeric polymerase complex of the virus, which is needed for viral replication and transcription. We developed the reagents for a fluorescence polarization assay, which can identify small molecules that disrupt the interactions within the complex, and have the potential to be a new anti-viral drug. This project also developed a transcription assay system to test the polymerase fidelity.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Thomas, Kelsey

Contributors

• Dewhurst, Stephen

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042811-123515

Advisor

• Adams, David S.

Year

• 2011

Sponsor

• University of Rochester

Date created

• 2011-04-28

Location

• Rochester

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

Last modified

• 2023-11-07