The proteins Mdm2 and MdmX are critical negative regulators of the tumor suppressor p53 and, when overexpressed, they function as oncogenes. However, recent research has shown MdmX to function as a tumor suppressor in p53-deficient mice and to increase genome stability in p53-deficient mouse cells. This project investigates the effect of MdmX on genomic stability in human breast cancer cells. The results show a correlation between MdmX and a decrease in multipolar spindles, along with an increase in chromosome number. These findings could provide a fundamental understanding of the role of genomic stability in human cancer.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Woods, Kevin Robert

Contributors

• Jones, Stephen N.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042213-174903

Advisor

• Adams, David S.

Year

• 2013

Sponsor

• UMass Medical School

Date created

• 2013-04-22

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

Last modified

• 2023-11-07