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C. elegans Transcription Cofactors

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Transcription Cofactors (TCFs) are essential non-DNA binding gene expression regulatory proteins. 162 TCFs were predicted within C. elegans using literature search and BLAST. Predicted TCFs consist of mediators, TAFs, nucleosome remodeling, modification, and tail binding proteins. Using a proprietary PSI-MI2.5 parser, 98 known interactions were queried with only 9 interactions with predicted Transcription factors (TFs). 45.7% predicted TCFs shows cause embryonic lethality from RNAi phenotypes. The predicted TCFs can be experimented with predict TFs to find novel interactions.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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Identifier
  • E-project-042910-154454
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Year
  • 2010
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Date created
  • 2010-04-29
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Last modified
  • 2021-02-02

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