Student Work

Study of Inhibitory Properties of Small Molecule Compounds on Histone Deacetylases

Public

Downloadable Content

open in viewer

Histones can undergo modifications, which regulate the accessibility of DNA. Modifications such as acetylation alter the epigenetic landscape, which regulates the expression of genes. Epigenetic regulations have been linked to important developmental stages of cardiovascular development. Because of their large clutch sizes, and transparent embryos, zebrafish are a useful for studying the effect of compounds believed to be epigenetic regulators. The aim of this project was to screen a library of small molecule compounds on zebrafish, for their effect on cardiovascular development. The library was screened on zebrafish, and thereafter analyzed by in vitro and in vivo assays. It was determined that six of these compounds had varying inhibitory properties on HDAC enzymes.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • E-project-042518-150146
Advisor
Year
  • 2018
Sponsor
Date created
  • 2018-04-25
Resource type
Major
Rights statement

Relations

In Collection:

Items

Items

Permanent link to this page: https://digital.wpi.edu/show/zk51vj240