Engineered tissues are being investigated for their role in drug research and development, however they lack the maturity and mechanical properties of dynamic in vivo tissue. The purpose of this project is to aid drug development, by developing a device that can efficiently actuate in vitro tissue scaffolds in order better observe the effects of cyclic actuating on improving the maturity and mechanical properties of engineered tissues. The final device has the ability to mechanically actuate scaffolds cyclically at varying strains and frequency while allowing for accurate imaging to calculate mechanical properties. The team conducted device verification tests to ensure strain accuracy and camera accuracy tests. The results determined that the device met our client objectives.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Velashea, Victoria Tianyu
• Dipersio, Thomas P.
• Chaffee, Benjamin Patrick
• Kowalczyk, Katherine Eleanor

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042519-135134

Advisor

• Billiar, Kristen

Year

• 2019

Date created

• 2019-04-25

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering
• Mechanical Engineering

Rights statement

• In Copyright