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Using β-Endorphin as an Opioid Addiction Model in C. elegans

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One of the most prominent addictions of the modern age is to opioids. While opioids originated as a pain relief treatment, their use has increased in the United States steadily since 1990. To study the impact of opioids on a compact neurological system, the model roundworm Caenorhabditis elegans was used. Beta-Endorphin, an endogenous human opioid, was administered to C. elegans and observed for changes in locomotive behavior. Our results revealed a reduction of speed of the worms treated with beta-Endorphin versus a water control. These findings suggest that beta-Endorphin has an effect on C. elegans and can be useful model in studying addiction in these systems

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042219-134900
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  • 2019
Date created
  • 2019-04-22
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