Student Work

Phytoestrogen Project: Effect of Promensil on T47D Breast Cancer Cells in Regards to the Cell Cycle and Estrogen Receptor Alpha

Public

Downloadable Content

open in viewer

Promensil is a plant-based postmenopausal medication containing phytoestrogens that mimic the structure of estrogen. Cell line treatments with Promensil were performed to study if it had any influence on the cell cycle regarding specific cell cycle proteins. Furthermore, T47D cells were administered MPP, an estrogen receptor-α specific antagonist, to verify if the Promensil antiproliferative mechanism is estrogen receptor-α mediated. Due to a variety of issues, it was not possible to make any conclusions about the effects of Promensil on the cell cycle. Promensil effects were still seen in cells treated with MPP, therefore it was determined that the antiproliferative effector pathway of Promensil is not estrogen receptor-α mediated, thus refuting the hypothesis.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • E-project-042419-161502
Advisor
Year
  • 2019
Date created
  • 2019-04-24
Resource type
Major
Rights statement

Relations

In Collection:

Items

Items

Permanent link to this page: https://digital.wpi.edu/show/r781wj38x