Faculty Advisor or Committee Member

Arne Gericke, Advisor

Identifier

etd-041916-215634

Abstract

Although phosphatidylinositol (PI) and phosphoinositides (PIPs) only comprise a small percentage of the inner leaflet of the plasma membrane, they mediate a large variety of signaling events. In previous studies, we have observed the absence of macroscopically discernible domains in mixtures of PI/PC and PI(4,5)P2/PC. The addition of cholesterol to these mixtures results in condensation of the monolayer and hence domain formation. To better mimic the ionic conditions and hydrogen bonding properties of the inner leaflet plasma membrane, we investigated in this study the effect of common inner leaflet plasma membrane lipids like phosphatidylethanolamine (PE), phosphatidylserine (PS) and PI, on phosphoinositide domain behavior in the presence of cholesterol and/or bivalent cations.

Publisher

Worcester Polytechnic Institute

Degree Name

PhD

Department

Chemistry & Biochemistry

Project Type

Dissertation

Date Accepted

2016-04-19

Accessibility

Unrestricted

Subjects

monolayer, plasma membrane, phospholipids, phosphoinositides, phosphatidylinositol

Share

COinS