Faculty Advisor or Committee Member

Nancy A Burnham, Advisor

Faculty Advisor or Committee Member

Terri A Camesano, Advisor

Faculty Advisor or Committee Member

Germano S Iannacchione, Committee Member

Identifier

etd-043015-110905

Abstract

Pseudomonas aeruginosa is extremely harmful to immunocompromised individuals. An atomic force microscope was used to measure the surface forces of this bacteria’s exopolymers. These forces were characterized with the AdG force model, which is a function of brush length, probe radius, temperature, separation distance and an indefinite density variable, s. This last parameter could represent the root spacing or mesh spacing of the exopolymers. This study aims to clarify s by obtaining force values as a function of temperature. The data suggest that s represents the mesh spacing. If s is the root spacing it should remain constant regardless of the changing polymer lengths, on the other hand if it is the mesh spacing it will vary with changing temperature, as shown by the data presented in this research. This knowledge will aid in understanding and characterizing how bacteria cause infections.

Publisher

Worcester Polytechnic Institute

Degree Name

MS

Department

Physics

Project Type

Thesis

Date Accepted

2015-04-30

Accessibility

Unrestricted

Subjects

Pseudomonas aeruginosa, Atomic Force Microscopy, AFM, AdG, Alexander and de Gennes

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