Faculty Advisor

Ki Chon

Faculty Advisor

David McManus

Faculty Advisor

Domhnull Granquist-Fraser

Abstract

Atrial fibrillation (AF) is a troublesome disease often overlooked by more serious myocardial infarctions. Up until now, there has been very little or no use of high order spectral techniques in order to evaluate the organization of the atrium during AF. Cross-bicoherence algorithm can be used alongside a surrogate data threshold in order to determine significant phase coupling interactions, giving rise to an organizational metric. This proposed algorithm is used to show rotigaptide, a gap junction coupling drug, significantly increases the organization of the atria during episodes of AF due to improvement of cell-to-cell coupling.

Publisher

Worcester Polytechnic Institute

Degree Name

MS

Department

Biomedical Engineering

Project Type

Thesis

Date Accepted

2011-05-19

Accessibility

Unrestricted

Subjects

atrial fibrillation, cardiac electrophysiology, cross-bispectrum, cross-bicoherence, high order spectral analysis, surrogate data

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