Faculty Advisor or Committee Member

Professor Kristen Wobbe, Advisor

Faculty Advisor or Committee Member

Norman Garceau, Committee Member

Faculty Advisor or Committee Member

Paul Wengender, Committee Member

Faculty Advisor or Committee Member

Professor William Hobey, Committee Member

Identifier

etd-053006-130545

Abstract

"Histone deacetylases (HDACs) have become one of the leading areas of research for cancer, neurodegenerative diseases, diabetes, obesity, and inflammation. Although HDACs are currently expressible in mammalian cultures and yeast, it is important to explore other cost effective options. Here it is shown that class I HDACs are expressible in insect cells. As well as expressing full length domains for class I HDACs, predicted active domains have also been expressed. This information can be utilized in many areas for future research including identifying unique sites to allow development of specific inhibitors for each HDAC, and developing a better understanding of the specific role of each HDAC. "

Publisher

Worcester Polytechnic Institute

Degree Name

MS

Department

Chemistry & Biochemistry

Project Type

Thesis

Date Accepted

2006-05-30

Accessibility

Unrestricted

Subjects

histone deacetylase, Histone deacetylase, Transcription factors

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