Faculty Advisor

Adams, David S.

Abstract

The goal of this project was to document and evaluate the technology of cancer vaccines, to determine whether they are worth the recent media hype, to document any associated problems, and to help prioritize future directions. We performed a review of the research literature and conducted interviews with academic cancer researchers. Based on the data, of the six major categories of cancer vaccines, tumor infiltrating lymphocyte (TIL) and chimeric antigen receptor (CAR) vaccines have shown the highest efficacies. In the future, we recommend using combination vaccines (especially with antibodies for immune checkpoint inhibitors), adjuvants, recall antigens, and identifying and using a patient¡¯s own specific tumor neo-antigens. We recommend that funding be continued for this research.

Publisher

Worcester Polytechnic Institute

Date Accepted

August 2015

Project Type

Interactive Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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