Faculty Advisor

Adams, David S.

Abstract

The purpose of this project was to document and evaluate the new breakthrough technology of human therapeutic cloning, finally achieved this year, and to assess the ethical problems associated with it. A literature review was performed followed by interviews with key scientists and ethicists. Our findings indicate that the use of human eggs is the most important ethical consideration in the process, and egg sources may become rate-limiting if the process is expanded to treat human diseases. Recommendations were made about frequently monitoring pluripotent cell lines for DNA mutations, epigenetic modifications, differentiation potential, tumor potential, and disease treatment, before and after expansion for clinical safety. We also identified a best-practice methodology for the cloning.

Publisher

Worcester Polytechnic Institute

Date Accepted

August 2014

Project Type

Interactive Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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