Faculty Advisor

Adams, David S.

Abstract

The purpose of this project was to investigate whether induced pluripotent stem cells (iPSCs) can potentially replace the more controversial embryonic stem cells (ESCs) in therapies. A literature review was performed followed by interviews with key stakeholders in the stem cell field. Our findings indicate that several potential problems exist with iPSCs before they can be used in human therapies, including their slow expansion, the potential for cancer, and the potential for immune-rejection of the injected cells. We identified several best-practice procedures for overcoming each of these problems, but conclude that more studies should be performed directly comparing the effectiveness of iPSCs versus ESCs for specific therapies.

Publisher

Worcester Polytechnic Institute

Date Accepted

August 2013

Project Type

Interactive Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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