Faculty Advisor

Albrecht, Dirk

Faculty Advisor

Orr, John A.

Project Center

Zurich, Switzerland


Due to economic, practical, and ethical reasons, many researchers are promoting more widespread adoption of alternative testing methods to replace existing animal tests. The most effective way to increase the use of these alternatives is to gain regulatory approval and instatement as guidelines through the Organisation for Economic Co-operation and Development (OECD). However, determining the exact approval process has been a major obstacle for many. Through information gathered from research and interviews, the process has been broken down into three main phases: development, validation, and regulatory acceptance. This report aims to provide a simplified guide for the approval process of alternative methods with a focus on nanomaterial assessments.


Worcester Polytechnic Institute

Date Accepted


Project Type

Interactive Qualifying Project



Advisor Department

Biomedical Engineering

Advisor Department

Electrical and Computer Engineering