Faculty Advisor

Pins, George D

Faculty Advisor

Sullivan, John M.

Abstract

In response to poor mechanical stability and long growth time of tissue-engineered skin substitutes, we present a novel skin-stretching device that mechanically stimulates engineered grafts during in vitro culture to accelerate growth. Mechanical loading increases epidermal proliferation, expression of growth factors, and mechanical stability. Our device loads engineered skin grafts at a customizable, cyclic waveform to ultimately lead to mechanically stable engineered skin grafts. ANSYS modeling approximated the maximum force to be applied at 0.2N. The device was fabricated and tested on porcine and chicken skin. After initial testing it was apparent the device could apply multiaxially load samples during culture. In addition, testing cycles can be varied to suit the user’s needs.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Mechanical Engineering

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

Advisor Department

Mechanical Engineering

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