Pins, George D
Sullivan, John M.
In response to poor mechanical stability and long growth time of tissue-engineered skin substitutes, we present a novel skin-stretching device that mechanically stimulates engineered grafts during in vitro culture to accelerate growth. Mechanical loading increases epidermal proliferation, expression of growth factors, and mechanical stability. Our device loads engineered skin grafts at a customizable, cyclic waveform to ultimately lead to mechanically stable engineered skin grafts. ANSYS modeling approximated the maximum force to be applied at 0.2N. The device was fabricated and tested on porcine and chicken skin. After initial testing it was apparent the device could apply multiaxially load samples during culture. In addition, testing cycles can be varied to suit the user’s needs.
Worcester Polytechnic Institute
Major Qualifying Project
All authors have granted to WPI a nonexclusive royalty-free license to distribute copies of the work, subject to other agreements. Copyright is held by the author or authors, with all rights reserved, unless otherwise noted.