Faculty Advisor

Srinivasan, Jagan

Center

University of Massachusetts Medical Center

Abstract

In the healthy brain, excitation/inhibition (E/I) balance regulates normal brain function. Microglia, the resident immune cells of the central nervous system, are intricately involved in brain homeostasis. The role of microglia in E/I balance was investigated using chemically induced seizures on mouse models with defective microglia and it was shown that the knockout models experienced increased seizure severity. Understanding the role of microglia in E/I balance will provide new insights into neuropsychiatric disorders such as Autism Spectrum Disorder.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2018

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Project Center

University of Massachusetts Medical Center

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