Faculty Advisor

Korkin, Dmitry

Abstract

In this project, the proteomes of Ebola and its deadly relatives from the Filoviridae (Filovirus) family are studied to better understand the evolution of these viruses that may help in developing better antiviral drugs and vaccines. Specifically, we construct three-dimensional models for the seven proteins in the proteome using the homology modeling approach. Then, we find the conserved and diverse regions in each protein across species and annotate them with the protein binding sites involved in virus-virus interactions and in human-virus interactions. We conclude that highly conserved regions are linked to the areas involved in virus-virus interactions, while the highly diverse regions are linked to those involved in human-virus interactions.

Publisher

Worcester Polytechnic Institute

Date Accepted

September 2015

Major

Bioinformatics and Computational Biology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Computer Science

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