Faculty Advisor

Jain, Anjana

Faculty Advisor

Page, Raymond L.

Abstract

In vitro tissue modeling of skeletal muscle has a potential role in understanding muscle tissue physiology. Current systems contain limitations including the presence of extracellular matrix and diffusion limitations. Our team developed a system that allows for sterile 3D tissue development, mimics in vivo attachment points, has a scaffold-less construction, and can mechanically stimulate developing muscle tissue in vitro. We believe this in vitro tissue model will not only allow a better understanding of developing muscle tissue, but can also be used as a screening modality for evaluation of future therapeutic treatments for muscle diseases and volumetric muscle loss.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

Share

COinS