In vitro tissue modeling of skeletal muscle has a potential role in understanding muscle tissue physiology. Current systems contain limitations including the presence of extracellular matrix and diffusion limitations. Our team developed a system that allows for sterile 3D tissue development, mimics in vivo attachment points, has a scaffold-less construction, and can mechanically stimulate developing muscle tissue in vitro. We believe this in vitro tissue model will not only allow a better understanding of developing muscle tissue, but can also be used as a screening modality for evaluation of future therapeutic treatments for muscle diseases and volumetric muscle loss.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Quinn, Caitlin Rebecca
• Aschettino, Michael Joseph
• Delfosse, Steven Joseph
• Larson, Katherine Marie

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042512-122709

Advisor

• Page, Raymond L.
• Jain, Anjana

Year

• 2012

Date created

• 2012-04-25

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright