Faculty Advisor

Adams, David S.

Abstract

Infection with Cryptococcus neoformans is responsible for the deaths of thousands of immunocompromised individuals worldwide annually. We hypothesized that the polarization of macrophages during infection of a murine model will provide evidence for the mechanisms of protection against this pathogen. We used FACS to assay specific markers on cells recruited to the lung during infection with various C. neoformans strains. This revealed a factor helpful in determining whether the mouse succumbs to infection, shifting the project to examine distinct eosinophil populations present in murine strains most susceptible to Cryptococcus. This information could aid in the vaccine development against C. neoformans.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2016

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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