Faculty Advisor

Adams, David S.

Abstract

Influenza virus hemagglutinin (HA) envelope protein aids in the recognition and attachment of the virion to host cell receptors. HA residues important for infection of the H5N1 type virus, an especially virulent type, are different than those previously characterized for other HA types. This project used mutagenesis to help identify H5 HA domains responsible for function. Of the 70 mutants tested, 25 showed infectivity levels similar to the WT, 24 showed no infectivity, 18 showed decreased infectivity, and 3 showed increased infectivity.

Publisher

Worcester Polytechnic Institute

Date Accepted

December 2011

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Share

COinS