Student Work

Mutagenesis of Influenza Virus H5-Type Hemagglutinin to Identify Domains Important for Infection

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Influenza virus hemagglutinin (HA) envelope protein aids in the recognition and attachment of the virion to host cell receptors. HA residues important for infection of the H5N1 type virus, an especially virulent type, are different than those previously characterized for other HA types. This project used mutagenesis to help identify H5 HA domains responsible for function. Of the 70 mutants tested, 25 showed infectivity levels similar to the WT, 24 showed no infectivity, 18 showed decreased infectivity, and 3 showed increased infectivity.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-121611-114248
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  • 2011
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  • 2011-12-16
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