Iron is the most physiologically abundant transition metal with diverse functions in cellular systems. The clinical significance of iron homeostasis warrants the development of accurate chemosensors which can detect Fe3+ under aqueous conditions. Due to their excellent photophysical properties, BODIPY fluorophores have been utilized in fluorescent Fe3+ sensors. Many published studies of these sensors identify iron binding to the probe as the source of the fluorescent signal. Fe3+ precipitates in water to produce iron(III) hydroxide, indicating that the fluorescence seen in the literature may not be caused by iron binding. The purpose of this project was to synthesize and characterize two BODIPY molecules to demonstrate Fe3+ binding is not necessary to induce a fluorescent response.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Lamica, Paige Anne

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042617-163225

Advisor

• Burdette, Shawn C

Year

• 2017

Date created

• 2017-04-26

Resource type

• Major Qualifying Project

Major

• Chemistry

Rights statement

• In Copyright

Last modified

• 2021-10-10