Burdette, Shawn C
Iron is the most physiologically abundant transition metal with diverse functions in cellular systems. The clinical significance of iron homeostasis warrants the development of accurate chemosensors which can detect Fe3+ under aqueous conditions. Due to their excellent photophysical properties, BODIPY fluorophores have been utilized in fluorescent Fe3+ sensors. Many published studies of these sensors identify iron binding to the probe as the source of the fluorescent signal. Fe3+ precipitates in water to produce iron(III) hydroxide, indicating that the fluorescence seen in the literature may not be caused by iron binding. The purpose of this project was to synthesize and characterize two BODIPY molecules to demonstrate Fe3+ binding is not necessary to induce a fluorescent response.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry