Faculty Advisor

Politz, Samuel M

Faculty Advisor

Prusty Rao, Reeta

Abstract

It is difficult to develop drugs against fungal infections due to the fact that both fungi and their hosts are eukaryotic. Using a model host-pathogen system, factors involved in the infection can be identified and studied. By using these two genetic model organisms and this assay in high-throughput screens of genetic knockouts, fungal virulence factors can be identified. We are developing a liquid culture assay for studying the effects of co-culturing Caenorhabditis elegans with Saccharomyces cerevisiae mutants. From the results of all the experiments, we concluded that there are other factors that can cause the death of the C. elegans in liquid assay which are not S. cerevisiae related.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2008

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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