Faculty Advisor

Rolle, Marsha W.

Abstract

A vascular bioreactor is a device that simulates an in vivo environment to improve the structure and function of tissue engineered vascular grafts (TEVGs). TEVGs should be cultured in a dynamic environment that provides luminal laminar flow; this facilitates nourishment of the cells and prevents occlusion of the graft. In this study, we designed, manufactured, and validated a novel bioreactor system for TEVGs. The bioreactor design successfully provided luminal laminar flow, incorporated an isolated flow loop, prevented leakage, remained sterile, limited mounting time, accommodated different sized samples, was easy to machine and cost effective.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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