Rolle, Marsha W.
A vascular bioreactor is a device that simulates an in vivo environment to improve the structure and function of tissue engineered vascular grafts (TEVGs). TEVGs should be cultured in a dynamic environment that provides luminal laminar flow; this facilitates nourishment of the cells and prevents occlusion of the graft. In this study, we designed, manufactured, and validated a novel bioreactor system for TEVGs. The bioreactor design successfully provided luminal laminar flow, incorporated an isolated flow loop, prevented leakage, remained sterile, limited mounting time, accommodated different sized samples, was easy to machine and cost effective.
Worcester Polytechnic Institute
Major Qualifying Project
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