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HVS'S ORF12 and the Downregulation of MHC-I

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K3 and K5 proteins encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) downregulate major histocompatibility complex class I (MHC-I) from the surface of host cells through ubiquitin-dependent endocytosis and degradation. The closest relative to KSHV is Herpesvirus saimiri (HVS) which naturally infects squirrel monkeys. The open reading frame (Orf) 12 of HVS shows a high structural homology to K3 and K5 proteins and thus, the functionality of Orf12 to downregulate MHC was tested. It was indeed found to be capable of downregulation.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-082205-145321
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  • 2005
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  • 2005-08-22
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