Faculty Advisor

Adams, David S.

Abstract

K3 and K5 proteins encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) downregulate major histocompatibility complex class I (MHC-I) from the surface of host cells through ubiquitin-dependent endocytosis and degradation. The closest relative to KSHV is Herpesvirus saimiri (HVS) which naturally infects squirrel monkeys. The open reading frame (Orf) 12 of HVS shows a high structural homology to K3 and K5 proteins and thus, the functionality of Orf12 to downregulate MHC was tested. It was indeed found to be capable of downregulation.

Publisher

Worcester Polytechnic Institute

Date Accepted

August 2005

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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