Student Work
Perturbation Analysis of a Potassium Channel Beta Subunit
PublicDownloadable Content
open in viewerKCNQ1 is a voltage-gated potassium channel that co-assembles with the KCNE family of transmembrane peptides. KCNQ1/KCNE3 channels are found in colonic crypt and airway epithelial cells and are constitutively conducting at normal resting potentials. Using site-directed mutagenesis, residues 87-96 in the C-terminus were mutated to alanine. The RNA of these mutants was microinjected into Xenopus oocytes and examined using a two-electrode voltage clamp. Results were compared to KCNE1 to determine the role of C-terminus in KCNQ1 modulation.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042606-192358
- Advisor
- Year
- 2006
- Date created
- 2006-04-26
- Resource type
- Major
- Rights statement
- Last modified
- 2020-12-27
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