Faculty Advisor

Duffy, Joseph B.

Abstract

Leucine rich repeat and Immunoglobulin domain (LIG) containing proteins play a critical role in protein-protein and intercellular interactions. While the extracellular domains of many of these proteins have been studied in depth, little is known about their intracellular domains, which can add to our knowledge of LIG protein functionality. Here, within the intracellular domains of two subfamilies of LIG molecules, the SALM and Linx subfamilies, sequences that are conserved over evolutionary time in four species: human, mouse, chicken, and elephant shark, have been identified and represent putative functionally relevant Short Linear Motifs, SLiMs.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2017

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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